Selected Papers | Structures |
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Selected Papers

Noncanonical DNA


1) AC-motif: a DNA motif containing adenine and cytosine repeat plays a role in gene regulation.
Nucleic Acids Res. 2021 Sep 1:gkab728.

2) The effect of hairpin loop on the structure and gene expression activity of the long-loop G-quadruplex.
Nucleic Acids Res. 2021 Aug 27:gkab739.

3) Genome-wide analysis of regulatory G-quadruplexes affecting gene expression in human cytomegalovirus
PLoS Pathog. 2018 Sep 28;14(9):e1007334.

4) Sequence preference and structural heterogeneity of BZ junctions.
Nucleic Acids Res. 2018 Nov 2;46(19):10504-10513.

5) Examining cooperative binding of Sox2 on DC5 regulatory element upon complex formation with Pax6 through excess electron transfer assay.
Nucleic Acids Res. 2016 Aug 19;44(14):e125.

6) Solution structure of the Z-DNA binding domain of PKR-like protein kinase (PKZ) from Carassius auratus and quantitative analyses of the intermediate complex during B-Z transition.
Nucleic Acids Res. 2016 Apr 7;44(6):2936-48.

7) Single molecule visualization and characterization of Sox2-Pax6 complex formation on a regulatory DNA element using a DNA origami frame.
Nano Lett. 2014 May 14;14(5):2286-92.

8) Distinct Z-DNA binding mode of a PKR-like protein kinase containing a Z-DNA binding domain.
Nucleic Acids Res. 2014 May 1;42(9):5937-48.

9 ) Solution structure of the Z-alph domain of human DAI and its binding modes to B- and Z-DNAs
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6921-6.

10) Intrinsic Z-DNA Is Stabilized by the Conformational Selection Mechanism of Z-DNA-Binding Proteins.
J Am Chem Soc. 2011 Feb 2;133(4):668-71.

11) Base extrusion is found at helical junctions between right- and left-handed forms of DNA and RNA.
Nucleic Acids Res. 2009 Jul;37(13):4353-59. Epub 2008 May 21

12) Crystal Structure of a B-DNA-Z-DNA junction Reveals Two Extruded Bases.
Nature. 2005 Oct 20;437(7062):1183-6.

Deubiquitinase & Protein homeostasis


1) Ubiquitin-Specific Protease 21 Promotes Colorectal Cancer Metastasis by Acting as a Fra-1 Deubiquitinase.
Cancers 2020, Jan 14; 12(1), 207.

2) A Selective Inhibitor of Ubiquitin-Specific Protease 4 Suppresses Colorectal Cancer Progression by Regulating b-catenin Signaling.
Cell Physiol Biochem 2019;53(1):157-171.

3) Ubiquitin-specific protease 4 (USP4) suppresses myoblast differentiation in a catalytic-independent manner.
Cellular signaling. 2017 Mar 21;35:48-60.

4) Ubiquitin-specific protease 4 controls metastatic potential through -catenin stabilization in brain metastatic lung adenocarcinoma.
Sci Rep. 2016 Feb 17;6:21596. doi: 10.1038/srep21596.

5) Ubiquitin specific protease 4 positively regulates the WNT/beta-catenin signaling in colorectal cancer.
Mol Oncol. 2015 Nov;9(9):1834-51.

6) Crystal Structure of a Small Heat-Shock Protein.
Nature. 1998 Aug 6;394(6693):595-9.

7) Small Heat Shock Protein of Methanococcus janaschii, a Hyperthermophile.
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9129-33.

Cell Reprogramming


1) Exosome-Mediated Differentiation of Mouse Embryonic Fibroblasts and Exocrine Cells into ет-Like Cells and the Identification of Key miRNAs for Differentiation.
Biomedicines. 2020 Nov 9;8(11):E485.
2) Chemical induced conversion of mouse fibroblasts and human adipose-derived stem cells into skeletal muscle-like cells.
Biomaterials. 2019 Feb;193:30-46.

3) Small molecule-induced cellular conversion.
Chem Soc Rev. 2017 Oct 16;46(20):6241-6254.

4) A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into cardiac mesoderm.
Nucleic Acids Res. 2017 Sep 19;45(16):9219-9228.

5) Combining suppression of stemness with lineage-specific induction leads to selective conversion of pluripotent cells into functional neurons.
Chemistry and Biology 2015 Nov 19;22(11):1512-20.

6) Inhibition of master transcription factors in pluripotent cells induces early stage differentiation.
Proc Natl Acad Sci U S A. 2014 Feb 14; 111(5): 1778-83.

Antimicrobial Resistance & Bacterial Signaling



1) An Antibacterial Nanorobotic Approach for the Specific Targeting and Removal of Multiple Drug-Resistant Staphylococcus aureus.
Small. 2021 Apr 10:e2100257.

2) Targeting Mannitol Metabolism as an Alternative Antimicrobial Strategy Based on the Structure-Function Study of Mannitol-1-Phosphate Dehydrogenase in Staphylococcus aureus.
MBio. 2019 Jul 9;10(4). pii: e02660-18.

3) Total synthesis of Xanthoangelol B and its various fragments: towards inhibition of virulence factor production of Staphylococcus aureus.
J Med Chem. 2018 Nov 2; 23, 10473?10487

4) Coupling of radiofrequency with magnetic nanoparticles treatment as an alternative physical antibacterial strategy against multiple drug resistant bacteria.
Sci Rep. 2016 Sep 27;6:33662.

5) Structural studies on the extracellular domain of sensor histidine kinase YycG from Staphylococcus aureus and its functional implications.
J Mol Biol. 2016 Jul 4. pii: S0022-2836(16)30241-8.

6) Structural insights into the molecular mechanism of Escherichia coli SdiA, a quorum-sensing receptor.
Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):694-707

7) Four Helical-Bundle Structure of the Cytoplasmic Domain of a Serine Chemotaxis Receptor.
Nature. 1999 Aug 19;400(6746):787-92.

Nanobiomaterials


1) Bioinorganic Nanohybrid Catalyst for Multistep Synthesis of Acetaminophen, an Analgesic.
ACS Appl. Mater. Interfaces.2016,8(44), pp 30058-30065.

2) Photocurrent enhancement of SiNW-FETs by integrating protein-shelled CdSe quantum dots
Nanoscale, 2016 Jan 28;8:1921-1925.

3) Distinct Rayleigh Scattering from Hot Spot Mutant p53 Proteins Reveals Cancer Cells.
Small. 2014 Jul;10(14):2954-62.

4) Radiofrequency treatment enhances the catalytic function of an immobilized nanobiohybrid catalyst
Nanoscale. 2014 Jun 7;6(11):6009-17.

5) Combining Protein-Shelled Platinum Nanoparticles with Graphene to Build a Bionanohybrid Capacitor.
ACS Nano. 2014 Dec 23;8(12):12120-9.

6) The effect of protein shells on the antioxidant activity of protein-encapsulated platinum nanoparticles
J. Mater. Chem., 2012 Feb 2:,22(5): 1774-1780.

7) Platinum nanoparticles encapsulated by aminopeptidase: a multifunctional bioinorganic nanohybrid catalyst
Angew Chem Int Ed Engl. 2011 Dec 9;50(50):11924-9.

structures

Structures deposited at Protein Data bank (PDB)

  Title date ID  
1 Maize nonspecific lipid transfer protein, uncomplexed 1995. 1. 27 1MZL 1.90
2 Bacillus licheniformis •·-amylase 1996. 10. 2 1VJS 1.70
3 Pseudomonas cepacia lipase 1996. 12. 6 1OIL 2.10
4 Pseudomonas fluorescens carboxylesterase 1997. 9. 1 1AUO 1.80
5 Pseudomonas fluorescens carboxylesterase, PMSF-complexed 1997. 9. 1 1AUR 2.50
6 Human cyclin H 1996. 8. 8 1KXU 2.6
7 Chicken Bc1 complex 1998. 9. 18 2BCC 3.5
8 Methanococcus Jannaschii Eukaryotic translation initiation factor 5A, tetragon 1998. 7. 29 1EIF 1.9
9 Methanococcus Jannaschii Eukaryotic translation initiation factor 5A, monoclinic 1998. 8. 12 2EIF 1.8
10 Methanococcus Jannaschii Small heat shock protein 1998. 7. 30 1SHS 2.9
11 Hypothetical protein MJ0577 from Methanococcus Jannaschii 1998. 11. 4 1MJH 1.7
12 Fibrillarin homologue from Methanococcus jannaschii 1999. 4. 25 1FBN 1.6
13 E. coli chemotaixs receptor 1999. 7. 7 1QU7 2.6
14 E. coli ribosome recycling factor 2000. 3 .7 1EK8 2.3
15 Protease domain of an ATP-independent heat shock protease HtrA 2002. 3. 1 1L1J 2.8
16 Brassica thioredoxin-h1 2002. progress 2.6
17 E.coli ribosome recycling factor mutant 2002. progress 2.4